Patients with this rare disease have a defect in the gene that controls a blood protein called C1
inhibitor. Because of the defect to this gene, a biochemical imbalance can occur and produce
unwanted peptides that induce the capillaries to release fluids into the surrounding tissue; thus
causing edema. Learn more about predictors of low patient activation when initiating C1 esterase inhibitor therapy for hereditary angioedema.